Human Reproduction, Vol 12, 830-834, Copyright © 1997 by Oxford University Press
RH Li and LZ Zhuang
The effects of growth factors were investigated on the proliferation of a
normal placental cytotrophoblast cell line (NPC). Epidermal growth factor
(EGF), transforming growth factor alpha (TGF alpha) and insulin- like
growth factor-I (IGF-I) stimulated NPC cell proliferation. In contrast,
TGFbeta1 was found to be a negative regulator, inhibiting EGF- induced cell
proliferation. When EGF/TGF alpha receptor was analysed by radio-ligand
binding, two binding sites of different affinities were revealed in the
proliferating NPC cells but only the low affinity binding site was detected
in the non-proliferating cytotrophoblast cells in primary cultures. The
results suggest that EGF stimulates cytotrophoblast proliferation through
high affinity binding sites.
ARTICLES
The effects of growth factors on human normal placental cytotrophoblast cell proliferation
Institute of Zoology, Chinese Academy of Sciences, Beijing.
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