Human Reproduction, Vol 12, 835-839, Copyright © 1997 by Oxford University Press
RJ Paulson, IE Hatch, RA Lobo and MV Sauer
The purpose of the present study was to determine the cumulative likelihood
of pregnancy success after repetitive cycles of oocyte donation and
specifically to examine the influence of recipient age and diagnosis upon
the cumulative likelihood of pregnancy in an effort to identify any
potential subgroup of recipients who might have diminished endometrial
receptivity. We retrospectively analysed the outcome of 418 consecutive
embryo transfer cycles among 276 recipients of oocyte donation in our
institution. We analysed clinical pregnancy and delivery rates in the
recipients divided by age groups and diagnostic groups. For the purpose of
life-table analysis, only cycles prior to and including the first cycle
producing a successful pregnancy were included. Frozen-thawed embryo
transfers were not included in the analysis. The overall clinical pregnancy
rate was 36.2% (95% CI 31-41%) and the cumulative pregnancy rate after four
cycles was 87.9%. The overall delivery rate was 29.3% (95% CI 25-33%) and
the cumulative delivery rate after four cycles was 86.1%. There were no
statistically significant differences in any of the rates attributable to
recipient age or diagnosis. No decline in per cycle success was noted over
consecutive cycles. We conclude that neither recipient age nor diagnosis
plays a substantial role in the success of oocyte donation, implying that
endometrial receptivity is unaltered by age or diagnosis. Furthermore, up
to four successive cycles of oocyte donation are associated with the same
probability of success.
ARTICLES
Cumulative conception and live birth rates after oocyte donation: implications regarding endometrial receptivity
Department of Obstetrics and Gynecology, University of Southern School of Medicine and USC IVF, California Medical Center, Los Angeles, USA.
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