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Human Reproduction, Vol 12, 1094-1097, Copyright © 1997 by Oxford University Press

ARTICLES

First-trimester repeated abortion is not associated with activated protein C resistance

J Balasch, JC Reverter, F Fabregues, D Tassies, M Rafel, M Creus and JA Vanrell
Department of Obstetrics and Gynaecology, Faculty of Medicine- University of Barcelona, Hospital Clinic i Provincial, Spain.

The present study was undertaken to investigate the possible association between activated protein C resistance and first-trimester repeated abortion. Fifty-five consecutive patients with unexplained first-trimester repeated abortion and 50 healthy control women having at least one child but no previous abortion were included. Activated protein C resistance was measured in all subjects and factor V Leiden genotype testing was performed in those individuals with phenotypic activated protein C resistance. One patient with first-trimester repeated abortion and one control subject had phenotypic activated protein C resistance. Genotype analysis confirmed that both subjects were heterozygous for factor V Leiden. Our results indicate that first- trimester repeated abortion is not associated with activated protein C resistance. Factor V Leiden screening in first-trimester repeated abortion is not warranted.
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