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Human Reproduction, Vol 12, 1563-1566, Copyright © 1997 by Oxford University Press

ARTICLES

A preliminary morphometric study on the endometrium from patients treated with indomethacin-releasing copper intrauterine device

G Zhao, M Li, P Zhu, R Xu, J Wang and R Xu
Pyong Yang Maternity Hospital, DPRK, Beijing, China.

The intrauterine device (IUD) is an effective method of birth control. However, IUD-induced uterine bleeding is a major side-effect and always causes inconvenience, sometimes even anaemia. It has been reported that oral administration of indomethacin could can reduce IUD-induced uterine bleeding. In the present study, we investigated whether indomethacin-releasing copper IUD (IR-Cu-IUD) can prevent insertion- induced uterine bleeding and its mechanism. Nine healthy volunteers of reproductive age were selected for the study. Endometrial tissues were collected at same menstrual stage prior to and 3-6 months after IR-Cu- IUD insertion. Endometrial morphology, cell proliferation/differentiation, morphometry and activity of complement Factor VIII were examined. No significant difference was found in any of the parameters examined in the same patients, both prior to and after IR-Cu-IUD insertion. By comparison with data previously obtained from the patients who had Cu-IUD insertions, it is clear that IR-Cu-IUD markedly reduced IUD-induced uterine bleeding and this reduction is primarily contributed by the anti-inflammatory action of indomethacin.
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