Human Reproduction, Vol 12, 1778-1784, Copyright © 1997 by Oxford University Press
P Dockery, RM Ismail, TC Li, MA Warren and ID Cooke
This study examined the fine structure of the human endometrial glandular
epithelium after the administration of a single dose of RU486
(mifepristone), given in the early luteal phase. The drug was administered
on days 2, 3, 5 and 6 after the luteinizing hormone peak (LH + 0). Biopsies
were performed on days LH + 5, 6, 8 and 9. These were compared with control
biopsies taken on corresponding days. Qualitatively, the main cytological
effect of the RU486 was on the secretory apparatus and on the polarity of
the cell. The formation of the nuclear channel system was also affected by
the drug. A two-way analysis of variance on cell and nuclear volume data
revealed no significant effect of day of biopsy, condition or interaction.
Mitochondrial volume and secretory apparatus volume data revealed a
significant effect of day of biopsy and interaction term; mitochondrial
volume at LH + 5 was 95.9 +/- 25.3 microm3 (mean +/- SD) for control and
57.7 +/- 31.9 microm3 for RU486-treated epithelium. The volume of the
secretory apparatus in the treated group was smaller on days LH + 5 and 6
(14.6 +/- 4.2 microm3, 6.41 +/- microm3) when compared to day- matched
control biopsies (35.9 +/- 10.5 microm3, 41.7 +/- 26.4 microm3). RU486
administration in the early luteal phase disrupted the secretory activity
of the cells. These findings provide an insight into the cellular
mechanisms of progesterone receptor blockade in the peri- implantation
period.
ARTICLES
The effect of a single dose of mifepristone (RU486) on the fine structure of the human endometrium during the early luteal phase
Department of Anatomy, University College, Cork, Ireland.
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