Human Reproduction, Vol 13, 1088-1093, Copyright © 1998 by Oxford University Press
I Sziller, SS Witkin, M Ziegert, Z Csapo, A Ujhazy and Z Papp
Clinical and histopathological correlations of immunoreactivity to
Chlamydia trachomatis and to epitopes of the C. trachomatis 60 kDa heat
shock protein (hsp60) among women with ectopic pregnancy were evaluated in
a case-control study. Serological responses to 13 synthetic peptides
corresponding to major epitopes of the chlamydial hsp60 were determined in
67 women treated for ectopic pregnancy and 45 women with uncomplicated
pregnancy in utero. Plasma cell salpingitis was detected in 29 (43.3%) of
the ectopic patients. Its presence correlated with antibodies to two hsp60
epitopes, encompassing amino acids 260-271 and 411-422 (P = 0.02).
Antibodies to these two epitopes, along with five other epitopes, also
correlated with peritubal adhesion formation in ectopic pregnant patients
(P < 0.01). Antibodies to epitopes 260-271 and 188-199 also correlated
with a history of pelvic inflammatory disease (PID; P = 0.05). Patients
with ectopic pregnancy were also more likely than their intrauterine
pregnant controls to have present anti- chlamydial immunoglobulin G (P <
0.005). Women positive for both C. trachomatis and hsp60 epitope antibodies
had an increased prevalence over controls of salpingitis, pelvic adhesions
or history of PID (P < 0.05). In contrast, patients who were positive
for only C. trachomatis antibodies or only hsp60 epitope antibodies did not
differ from antibody-negative patients in each of these categories.
ARTICLES
Serological responses of patients with ectopic pregnancy to epitopes of the Chlamydia trachomatis 60 kDa heat shock protein
First Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest, Hungary.
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