Human Reproduction, Vol 13, 1502-1505, Copyright © 1998 by Oxford University Press
AM Clark, B Thornley, L Tomlinson, C Galletley and RJ Norman
Obesity affects ovulation, response to fertility treatment, pregnancy rates
and outcome. In this prospective study, a weight loss programme was
assessed to determine whether it could help obese infertile women,
irrespective of their infertility diagnosis, to achieve a viable pregnancy,
ideally without further medical intervention. The subjects underwent a
weekly programme aimed at lifestyle changes in relation to exercise and
diet for 6 months; those that did not complete the 6 months were treated as
a comparison group. Women in the study lost an average of 10.2 kg/m2, with
60 of the 67 anovulatory subjects resuming spontaneous ovulation, 52
achieving a pregnancy (18 spontaneously) and 45 a live birth. The
miscarriage rate was 18%, compared to 75% for the same women prior to the
programme. Psychometric measurements also improved. None of these changes
occurred in the comparison group. The cost savings of the programme were
considerable. Prior to the programme, the 67 women had had treatment
costing a total of A$550,000 for two live births, a cost of A$275,000 per
baby. After the programme, the same women had treatment costing a total of
A$210,000 for 45 babies, a cost of A$4600 per baby. Thus weight loss should
be considered as a first option for women who are infertile and overweight.
ARTICLES
Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment
Department of Obstetrics and Gynaecology, The Queen Elizabeth Hospital, University of Adelaide, Woodville, SA, Australia.
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