Human Reproduction, Vol 13, 1702-1705, Copyright © 1998 by Oxford University Press
J Moise, A Laor, Y Armon, I Gur and R Gale
It has been suggested that the high rates of prematurity, low birth weight,
perinatal morbidity and mortality in in-vitro fertilization (IVF) infants
are due to the increased frequency of multiple gestations in this
population. The aim of our study was to test this hypothesis by comparing
the outcome of IVF twins with that of twins born after spontaneously
conceived pregnancies. The perinatal outcome of 40 IVF twins was compared
with that of 80 control twins, matched for maternal age, parity and ethnic
origin. IVF twins had a higher rate of prematurity (P = 0.03), their mean
birth weight was significantly lower (P < 0.01) and the frequency of
very low birth weight infants was much higher (P < 0.003). There was no
neonatal mortality in the control group, whereas four IVF twins died (P
< 0.01). Neonatal morbidity was significantly greater in IVF twins (P
< 0.05). Oxygen therapy and mechanical ventilation were administered
more frequently to IVF twins (P < 0.007 and P < 0.05). We conclude
that twins conceived by IVF are at a significantly higher risk for
prematurity and associated neonatal morbidity and mortality than
spontaneously conceived twins.
ARTICLES
The outcome of twin pregnancies after IVF
Department of Neonatology and NICU, Bikur Cholim Hospital, Jerusalem, Israel.
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