Human Reproduction, Vol 13, 1801-1803, Copyright © 1998 by Oxford University Press
B Benzacken, JP Siffroi, B Straub, C Le Bourhis, S Sauvion, J Gaudelus, JP Dadoune and JP Wolf
We report one case of a de-novo complex chromosomal rearrangement (CCR),
t(1;5;13)ins(14;13), in an abnormal 19-month-old boy. Clinical features
associated were a mild facial dysmorphy and a psychomotor retardation.
Parental ages were, respectively, 29 years for the mother and 60 years for
the father. We point out the usefulness of fluorescence in-situ
hybridization in elucidating CCRs, and discuss the possible correlation
between the existence of a chromosomal aberration and advanced paternal
age.
ARTICLES
Advanced paternal age and de-novo complex chromosomal rearrangement in offspring
Laboratoire d'Histologie, Embryologie, Cytogenetique et Biologie de la Reproduction, Hopital Jean Verdier, Bondy, France.
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