Human Reproduction, Vol 13, 2411-2414, Copyright © 1998 by Oxford University Press
F Olivennes, S Alvarez, P Bouchard, R Fanchin, J Salat-Baroux and R Frydman
New gonadotrophin-releasing hormone (GnRH) antagonists, which allow
suppression of luteinizing hormone (LH) surges, have recently become
available. We compared in this study the results of a single administration
of 3 versus 2 mg Cetrorelix in 65 patients undergoing ovarian stimulation
and in-vitro fertilization (IVF). The GnRH antagonist (Cetrorelix) was
non-randomly administered at a dose of 3 mg (34 patients) or 2 mg (32
patients) on day 8 of the stimulation cycle. In the case of slow follicular
development, the injection was delayed until oestradiol reached 400 pg/ml.
No difference was observed in the decrease in LH and in oestradiol
secretion between the 3 and the 2 mg groups, but the LH secretion was
suppressed for a shorter time in the 2 mg group. No LH surge was observed
in the 3 mg group, while one surge (3%) and one significant rise in LH were
observed in the 2 mg group. No significant difference was observed in IVF
results in the two groups of patients. This study demonstrates that a
single injection of 3 or 2 mg successfully prevents LH surges for at least
3 days in all the patients treated. The LH rises in the 2 mg group led us
to choose the 3 mg dose as a safer dose in our single administration
protocol.
ARTICLES
The use of a GnRH antagonist (Cetrorelix) in a single dose protocol in IVF-embryo transfer: a dose finding study of 3 versus 2 mg
Department of Obstetrics and Gynecology, A.Beclere Hospital, Clamart, France.
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