Human Reproduction, Vol 13, 2564-2567, Copyright © 1998 by Oxford University Press
B Balaban, B Urman, A Sertac, C Alatas, S Aksoy and A Nuhoglu
Excess embryos from patients undergoing intracytoplasmic sperm injection
and embryo transfer for male infertility were cultured to determine the
rate and timing of their progression to the blastocyst stage. In 194 embryo
transfer cycles, four embryos with the morphologically best grading were
transferred and at least two embryos were cultured. The cycles were
classified as: group 1: no excess embryos reached blastocyst stage, group
2: >50% of embryos reached blastocyst stage by days 4-5, group 3:
<50% of embryos reached the blastocyst stage by days 4-5, group 4:
>50% of the embryos reached blastocyst stage by days 6-7, group 5:
<50% of the embryos reached blastocyst stage by days 6-7. All groups
were similar regarding female age, duration of infertility, and parameters
of ovarian stimulation. In group 1, clinical pregnancy and implantation
rates were 14 and 11% respectively, and were similar to those of group 4.
In group 2, clinical pregnancy and implantation rates were 75 and 33%.
Multiple implantations occurred in 81% of group 2 or 3 cycles, compared to
none in group 1 cycles. The results suggest that the development potential
of the embryo is intrinsic, and that embryos which carry a high potential
for development yield a high clinical pregnancy rate and multiple
implantations.
ARTICLES
Progression of excess embryos to the blastocyst stage predicts pregnancy and implantation rates after intracytoplasmic sperm injection
Assisted Reproductive Technology Unit, American Hospital of Istanbul, Turkey.
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