Human Reproduction, Vol. 14, No. 1, 167-171,
January 1999
© 1999 European Society of Human Reproduction and Embryology
The outcome of in-vitro fertilization treatment in women with sonographic evidence of polycystic ovarian morphology
1 The London Women's Clinic, 115 Harley Street, London, 2 Department of Obstetrics and Gynaecology, Royal Victoria Hospital, McGill University, Montreal, Canada, 3 Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine and 4 Department of Obstetrics and Gynaecology, St. George's Hospital Medical School, London, UK
This study compared the outcome of a course of up to three cycles of in-vitro fertilization (IVF) treatment in 46 women (97 cycles) who had polycystic ovaries (PCO) seen on ultrasound scan, but who had no clinical symptomatology associated with polycystic ovary syndrome, with that of 145 women (332 cycles) who had normal ovarian morphology on ultrasound examination. All 191 women had normal early follicular phase serum follicle stimulating hormone (FSH) concentrations, were less than 40 years of age and used the long protocol of pituitary suppression with gonadotrophin-releasing hormone agonist therapy. On average, the women with PCO produced more follicles, oocytes and embryos than the women with normal ovaries, but the fertilization, cleavage and miscarriage rates were similar. Adjusted for age, the odds of achieving a pregnancy within three cycles of treatment in a woman with PCO were 69% higher than those of a woman with normal ovaries [odds ratio (OR): 1.69, 95% confidence interval (CI) 0.99–2.90, P = 0.05)] and the odds of achieving a live birth were 82% higher (OR: 1.82, 95% CI 1.05–3.16, P = 0.03). There is, therefore, evidence that outcome of IVF treatment for women with PCO seen on ultrasound examination may be better than that for women with normal ovaries.
Key words: IVF/normal ovary/outcome/ovarian response/PCO
5 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Royal Victoria Hospital, McGill University, 687 Pine Avenue West, Montreal QC H3A 1A1, Canada
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