Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (15)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Sharara, F. I.
Right arrow Articles by McClamrock, H. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sharara, F. I.
Right arrow Articles by McClamrock, H. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 14, No. 1, 183-185, January 1999
© 1999 European Society of Human Reproduction and Embryology

The effect of pituitary desensitization on ovarian volume measurements prior to in-vitro fertilization

Fady I. Sharara1,3, Joanne Lim2 and Howard D. McClamrock1

1 Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine and 2 University of Maryland School of Medicine, Baltimore, USA

The measurement of ovarian volume has been recently shown to predict follicular response in in-vitro fertilization (IVF), specifically a lower number of retrieved oocytes with decreasing ovarian volume. This test appears to be better than basal follicle-stimulating hormone (FSH) as a prognostic measure of ovarian reserve. However, the effect of pituitary desensitization on ovarian volume has not been previously investigated. We prospectively evaluated 38 women undergoing IVF using a long luteal leuprolide acetate (LA) protocol. All women had their ovarian volume measurements performed on day 21, the day of LA start, and again on the day of gonadotrophin start. The mean age was 30.6 ± 3.9 years (range 23–37). Basal FSH was 5.4 ± 1.9 IU/l (range 1.2–10.2). The mean preLA ovarian volume was 7.0 ± 3.6 cm3 (left ovary 6.8 ± 3.9, right ovary 7.1 ± 3.8), compared to 6.3 ± 4.2 cm3 postLA (left ovary 6.0 ± 4.9, right ovary 6.5 ± 4.8) (not significant). The mean number of small antral follicles noted in both ovaries was also unchanged after pituitary desensitization. Pituitary desensitization using LA had no effect on overall ovarian volume measurements. The total number of retrieved oocytes decreased with increasing age and decreasing ovarian volume.

Key words: IVF/leuprolide acetate/ovarian volume/ultrasound

3 To whom correspondence should be addressed at: 405 W. Redwood St, Baltimore, MD 21201, USA


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
K. Jayaprakasan, J.F. Hopkisson, B.K. Campbell, J. Clewes, I.R. Johnson, and N.J. Raine-Fenning
Quantification of the effect of pituitary down-regulation on 3D ultrasound predictors of ovarian response
Hum. Reprod., July 1, 2008; 23(7): 1538 - 1544.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. Balasch, F. Fabregues, J. Penarrubia, F. Carmona, R. Casamitjana, M. Creus, D. Manau, G. Casals, and J. A. Vanrell
Pretreatment with transdermal testosterone may improve ovarian response to gonadotrophins in poor-responder IVF patients with normal basal concentrations of FSH
Hum. Reprod., July 1, 2006; 21(7): 1884 - 1893.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. H. Y. Ng, C. C. W. Chan, O. S. Tang, and P. C. Ho
Antral follicle count and FSH concentration after clomiphene citrate challenge test in the prediction of ovarian response during IVF treatment
Hum. Reprod., June 1, 2005; 20(6): 1647 - 1654.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C.C.W. Chan, E.H.Y. Ng, C.F. Li, and P.C. Ho
Impaired ovarian blood flow and reduced antral follicle count following laparoscopic salpingectomy for ectopic pregnancy
Hum. Reprod., October 1, 2003; 18(10): 2175 - 2180.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. Dada, O. Salha, V. Allgar, and V. Sharma
Utero-ovarian blood flow characteristics of pituitary desensitization
Hum. Reprod., August 1, 2001; 16(8): 1663 - 1670.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
F. I. Sharara and H. D. McClamrock
Use of microdose GnRH agonist protocol in women with low ovarian volumes undergoing IVF
Hum. Reprod., March 1, 2001; 16(3): 500 - 503.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.