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Human Reproduction, Vol. 14, No. 1, 207-210, January 1999
© 1999 European Society of Human Reproduction and Embryology

Effect of 6ß-methylprednisolone on mouse pregnancy rate

Esther Velilla, Mark Grossmann, Josep Egozcue and Josep Santaló1

Departament de Biologia Cel·lular i Fisiologia, Edifici C, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain

The aim of this study was to evaluate the effect of methylprednisolone on the pregnancy rate in mice. For this reason, zona pellucida-intact and zona pellucida-free embryos at the blastocyst stage were transferred to recipient mice at day 2.5 of pseudopregnancy. Embryo transfer was performed into non-immunodepressed and immunodepressed groups of recipient mice using 0.3 or 0.6 µg/g of 6ß-methylprednisolone. A higher implantation and developmental rate of zona-free embryos transferred to the immunodepressed group of recipients was observed after using the higher dose of methylprednisolone.

Key words: developmental rate/embryo transfer/immunodepression/implantation rate/methylprednisolone

1 To whom correspondence should be addressed


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