Human Reproduction, Vol. 14, No. 10, 2448-2450,
October 1999
© 1999 European Society of Human Reproduction and Embryology
Factor V Leiden and factor II G20210A mutations in patients with recurrent abortion
1 Sector of Human Reproduction, Department of Gynecology and Obstetrics and 2 Department of Clinical Medicine, Faculty of Medicine of Ribeirão Preto, 14049-900 Ribeirão Preto, SP, 3 Department of Gynecology and Obstetrics, Faculty of Medicine of Botucatu, SP, and 4 Blood Center of Ribeirão Preto (FUNDHERP), SP, Brazil
Recurrent abortion (RA) represents an intriguing problem in obstetric practice in which genetic and acquired factors may play a role. In the present investigation we sought to assess the possibility that inherited thrombophilia might determine the risk of RA. We therefore investigated the prevalence of two genetic abnormalities frequently associated with venous thrombosis [factor V Leiden (FVL) and factor II G20210A] in 56 patients with primary or secondary abortion and in 384 healthy control women. Polymerase chain reaction amplification followed by digestion with the restriction enzymes MnlI and HindIII was used to define the FVL and FII G20210A genotypes respectively. FVL was found in 4/56 patients (7.1%) and in 6/384 controls (1.6%), yielding an odds ratio (OR) for RA related to FVL of 4.9 [95% confidence interval (CI): 1.3–17.8]. FII G20210A was detected in 2/56 (3.6%) patients and in 4/384 (1%) controls (OR for RA: 3.5, CI: 0.6–19.7). In conclusion, FVL and FII G20210A mutations in patients with RA were more prevalent in comparison with controls. These data support a role for both mutations as determinants of the risk of RA and strengthen the notion that thrombophilia plays a role in this clinical entity.
Key words: factor V Leiden/factor II G20210A/recurrent abortion/risk factor/thrombophilia
5 To whom correspondence should be addressed. E-mail: raferria{at}fmrp.usp.br
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