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Human Reproduction, Vol. 14, No. 10, 2451-2454, October 1999
© 1999 European Society of Human Reproduction and Embryology

No mutations found in candidate genes for dystocia

Michael Algovik1,2, Jacob Lagercrantz3, Magnus Westgren1 and Agneta Nordenskjöld3,4,5

1 Department of Obstetrics and Gynaecology, Huddinge Hospital, Stockholm, 2 Department of Obstetrics and Gynaecology, Västervik Hospital, 3 Department of Molecular Medicine, CMM 02, Karolinska Hospital, Stockholm and 4 Department of Paediatric Surgery, Astrid Lindgren Children Hospital, Karolinska Hospital, Stockholm, Sweden

Dystocia is a disorder characterized by prolonged or dysfunctional labour. Delivery that starts late or not at all, leads to an increased risk for Caesarean section, infant morbidity and mortality. Familial aggregations of dystocia suggest a polygenic background. We have studied three candidate genes for dystocia, i.e. the genes for testosterone 5-{alpha} reductase type 1, prostaglandin F2{alpha} receptor and endothelin 1 and performed mutational screening in 23 women with dystocia, of which 12 have affected relatives. No mutations were found, making it unlikely that any of these genes represent a major cause of dystocia in man.

Key words: dystocia/endothelin 1 gene/mutational screening/prostaglandin F2{alpha}-receptor gene/testosterone 5 {alpha} reductase type 1 gene

5 To whom correspondence should be addressed at: Department of Molecular Medicine, CMM 02, Karolinska Hospital, S-171 76 Stockholm, Sweden


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