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Human Reproduction, Vol. 14, No. 10, 2562-2564, October 1999
© 1999 European Society of Human Reproduction and Embryology

Shortened exposure of oocytes to spermatozoa improves in-vitro fertilization outcome: a prospective, randomized, controlled study

M. Dirnfeld1,3, D. Bider2, M. Koifman1, I. Calderon1 and H. Abramovici1

1 IVF Units, Carmel Hospital, Rambam Medical Center, TECHNION and The Rappaport Faculty of Medicine, Haifa and 2 Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Israel

A prospective, randomized study of 158 patients undergoing in-vitro fertilization (IVF) and embryo transfer was conducted to evaluate whether a shortened exposure of oocytes to spermatozoa enhances oocyte development, and subsequently influences the IVF outcome. A comparison was made between conventional treatment time and shorter exposure of retrieved oocytes to spermatozoa. Fertilization and cleavage rates, embryo quality, implantation and pregnancy rates in the study group (short exposure) versus controls (standard IVF procedure) were evaluated. Fertilization (56 versus 61%) and cleavage rates (96 versus 92%) were similar in the two groups respectively. However, embryo quality was significantly higher in the study group (P < 0.05). Moreover, the pregnancy and implantation rates were significantly increased (42.4 versus 26% per embryo transfer, and 16 versus 10% respectively; P < 0.05). Our results demonstrated that shorter exposure of oocytes to spermatozoa is superior to the standard time in IVF and may have a favourable effect on implantation rates by improving embryo quality.

Key words: embryo quality/implantation rate/in-vitro fertilization/pregnancy rates/zona hardening

3 To whom correspondence should be addressed at: IVF Unit, Department of Obstetrics and Gynecology, Carmel Medical Center, 7 Michal Street, 34362 Haifa, Israel


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