Human Reproduction, Vol. 14, No. 10, 2661-2664,
October 1999
© 1999 European Society of Human Reproduction and Embryology
Non-functioning pituitary tumour after long-term treatment with gonadotrophin-releasing hormone agonists in a patient with vaginal agenesis who underwent neovaginoplasty and cauterization of endometriosis under laparoscopy: Case Report
1 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, 2 CREST, Japan Science and Technology, Kawaguchi and 3 Department of Obstetrics and Gynecology, Teikyo University School of Medicine, Ichihara Hospital, Ichihara, Japan
Vaginal agenesis combined with a functional uterus is a rare condition in which treatment modalities that preserve reproductive function are controversial. A 21 year old female presented with congenital vaginal agenesis combined with cervical atresia. She was treated with gonadotrophin-releasing hormone (GnRH) agonists for a total period of over 5 years when a non-functioning pituitary tumour was detected by brain magnetic resonance imaging (MRI). A laparoscopically assisted reconstruction of a neovagina and neoendocervical canal was performed utilizing lyophilized porcine dermal skin to line the neovagina. Endometriosis of the pelvis was revealed and adhesiolysis and cauterization were also carried out under laparoscopy. The GnRH agonist was discontinued and the patient resumed cyclic menses with no abdominal pain. The pituitary tumour decreased in size 6 months after the cessation of GnRH agonists. We raise the question as to whether pituitary MRI should be performed for patients who need long-term administration of GnRH agonists.
Key words: cervical atresia/GnRH agonist/laparoscopic surgery/pituitary tumour/vaginal agenesis
4 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7–3–1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan