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Human Reproduction, Vol. 14, No. 11, 2788-2790, November 1999
© 1999 European Society of Human Reproduction and Embryology

Contraceptive efficacy of daily administration of 0.5 mg mifepristone

Lena Marions1,3, Sandor Viski2, Kristina Gemzell Danielsson1, Bela A. Resch2, Marja-Liisa Swahn1, Marc Bygdeman1 and László Kovâcs2

1 Department of Woman and Child Health, Division for Obstetrics and Gynecology, Karolinska Hospital, S-171 76 Stockholm, Sweden and 2 Department of Obstetrics and Gynecology, Albert Szent-Györgyi, Medical University Szeged, Hungary

The antiprogestin mifepristone has shown potential to be used as a contraceptive. If 200 mg mifepristone is administered immediately after ovulation, the endometrium shows sufficient impairment of secretory development to prevent implantation. Low daily doses of mifepristone have been shown to reduce several of the local factors regarded as crucial for implantation in human endometrium. To find out if this regimen is sufficient to prevent pregnancy, 32 women were recruited for a study where 0.5 mg mifepristone was administered daily. A total of 141 cycles were studied. Five pregnancies occurred, which was significantly less than if no contraceptive method had been used. However, the dose chosen did not seem sufficient to act as a contraceptive although it is probably not possible to increase the dose without disturbing ovulation and bleeding pattern.

Key words: antiprogestin/contraception/implantation/mifepristone

3 To whom correspondence should be addressed


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