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Human Reproduction, Vol. 14, No. 2, 318-320, February 1999
© 1999 European Society of Human Reproduction and Embryology

Subfertile men with constitutive chromosome abnormalities do not necessarily refrain from intracytoplasmic sperm injection treatment: a follow-up study on 75 Dutch patients

J.C. Giltay1,13, P.M.M. Kastrop2, J.H.A.M. Tuerlings3, JA.M. Kremer3, C.H.J. Tiemessen4, K.B.J. Gerssen-Schoorl5, F. van derVeen6, J. deVries6, R. Hordijk7, G.J.H. Hamers8, K. Hansson9, M. van der Blij-Philipsen10, L.C.P. Govaerts11, M.H.E.C. Pieters11, K. Madan12 and J.M.J.C. Scheres1

1 Clinical Genetics Center Utrecht, 2 University Hospital Utrecht, 3 University Hospital Nijmegen, 4 Elisabeth Hospital, Tilburg, 5 Streeklaboratorium Enschede, 6 Academic Medical Center, Amsterdam, 7 University of Groningen, 8 University of Maastricht, 9 University Hospital Leiden, 10 St. Erfelijkheidsonderzoek Noord Brabant, Veldhoven, 11 University Hospital Dijkzigt, Rotterdam and 12 University Hospital, Vrije Universiteit, Amsterdam,The Netherlands

A follow-up study was performed to investigate the impact of the detection of a chromosome abnormality in infertile men who are candidates for intracytoplasmic sperm injection (ICSI) treatment. In this collaborative study between clinical genetics centres and fertility clinics in the Netherlands, 75 ICSI couples of which the male partners had a chromosome abnormality were included. All couples were extensively counselled on the risk of having a chromosomally unbalanced child. Forty-two out of 75 couples chose to proceed with the ICSI treatment. So far, treatment has resulted in a pregnancy in 11 cases. Four of them opted to have invasive prenatal diagnosis. Despite the genetic risks related to a chromosome abnormality in infertile men, a small majority (56%) of the couples did not refrain from the ICSI treatment.

Key words: chromosome abnormality/follow-up/intracytoplasmic sperm injection (ICSI)/male infertility/oligoasthenoteratozoospermia (OAT)

13 To whom correspondence should be addressed at: Clinical Genetics Center Utrecht, P.O. Box 18009, 3501 CA Utrecht,The Netherlands


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