Human Reproduction, Vol. 14, No. 2, 345-348,
February 1999
© 1999 European Society of Human Reproduction and Embryology
Propofol concentrations in follicular fluid during general anaesthesia for transvaginal oocyte retrieval
1 Department of Anaesthesiology and 2 Centre for Reproductive Medicine, Department of Anaesthesiology, University Hospital A.Z. – V.U.B., Flemish Free University of Brussels, Laarbeeklaan 101, B-1090 Brussels, Belgium
Propofol (Diprivan®) is an i.v. anaesthetic used for general anaesthesia. The purpose of this study was to measure the propofol concentration in arterial blood and follicular fluid in patients during transvaginal oocyte retrieval. After approval by the University Ethics Committee, 30 women participated in this prospective study. Following induction of anaesthesia with 0.5 mg alfentanil and 2 mg.kg–1 propofol i.v., a continuous infusion of propofol at 10 mg.kg–1.h–1 was used for maintenance of anaesthesia. Follicular fluid and arterial blood samples were aspirated simultaneously at fixed intervals during the surgical procedure and propofol assayed by high pressure liquid chromatography (HPLC). The mean follicular fluid concentration of propofol increased linearly with time from 0.10 ± 0.02 µg.ml–1 to 0.57 ± 0.06 µg.ml–1 and was strongly related to the cumulative dose of propofol administered. The absorption of propofol was time-dependent. There was no correlation between the concentration of propofol in the follicular fluid and the arterial blood concentration of the drug. In conclusion, a propofol-based anaesthetic technique resulted in significant concentrations of this agent in follicular fluid, related to the dose administered and to the duration of propofol administration.
Key words: anaesthesia/arterial blood/follicular fluid/oocyte/propofol
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