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Human Reproduction, Vol. 14, No. 4, 1137-1138, April 1999
© 1999 European Society of Human Reproduction and Embryology

Letters to the Editor

A 47,XXY fetus resulting from ICSI in a man with an elevated frequency of 24,XY spermatozoa

Nafisa Moosani, Judy Chernos, R.Brian Lowry and Renee H. Martin1

Department of Medical Genetics, Faculty of Medicine, University of Calgary, and Genetics Department, Alberta Children's Hospital, 1820 Richmond Road SW, Calgary, Alberta T2T 5C7, Canada

Alfred Rademaker

Cancer Center, Biometry Section, Northwestern University Medical School, Chicago, IL, USA

Dear Sir,

There has been considerable debate and controversy about genetic risks associated with intracytoplasmic sperm injection (ICSI) (Martin, 1996Go; Persson et al., 1996Go). As well as concerns about the increased frequency of the cystic fibrosis transmembrane regulator mutations and Y chromosome deletions in infertile males, there is also mounting evidence of increased risks for chromosomal abnormalities following ICSI. Studies of infertile men have repeatedly demonstrated . . . [Full Text of this Article]

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