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Human Reproduction, Vol. 14, No. 4, 889-892, April 1999
© 1999 European Society of Human Reproduction and Embryology

Clinical outcome after unilateral oophorectomy in patients with polycystic ovary syndrome

Eugenie M. Kaaijk1,2,3, Johan V.T.H. Hamerlynck1, Johan F. Beek2 and Fulco van der Veen1

1 Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology and 2 Laser Centre, Academic Medical Centre, PO Box 22700, 1100 DE, Amsterdam, The Netherlands

The objective of this study is to report retrospectively on the clinical outcome of unilateral oophorectomy in 14 women with polycystic ovary syndrome who had undergone this treatment 14–18 years ago in our hospital for clomiphene citrate-resistant anovulation and long standing infertility or for severe hirsutism. The main outcome measures were menstrual cycle, pregnancy, hirsutism, testosterone concentrations, and premature ovarian failure. Unilateral oophorectomy restored regular menstrual cycles in 12 of the 14 patients. Thirteen years later, nine out of 12 patients still had regular menstrual cycles. Ten patients wished to become pregnant. Seven of them conceived spontaneously. Eleven patients complained of severe hirsutism. After unilateral oophorectomy, hirsutism regressed subjectively in six. Testosterone blood concentrations decreased significantly within the first year after unilateral oophorectomy in 11 patients. None of the women entered menopause within 14–18 years after surgery. Our results indicate that unilateral oophorectomy restores ovulatory function for many years in the majority of patients and does not result in premature ovarian failure. However, unilateral oophorectomy should not be recommended as a standard treatment for clomiphene citrate-resistant patients with polycystic ovary syndrome.

Key words: hirsutism/hormone status/menstrual cycle/polycystic ovary syndrome/pregnancy/premature ovarian failure

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