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Human Reproduction, Vol. 14, No. 4, 982-985, April 1999
© 1999 European Society of Human Reproduction and Embryology

A comparison of the inhibition of ovulation achieved by desogestrel 75 µg and levonorgestrel 30 µg daily

C.F. Rice1,3, S.R. Killick1, T. Dieben2 and H.Coelingh Bennink2

1 Department of Obstetrics and Gynaecology, The Princess Royal Hospital, Saltshouse Road, Hull HU8 9HE, UK and 2 Clinical Development Department, NV Organon, Oss, The Netherlands

A randomized, double blind, group comparative study was performed over a 12 month period to compare inhibition of ovulation during the use of two (progestogen-only) oral contraceptives containing doses of 75 µg desogestrel or 30 µg levonorgestrel. Seventy-one female volunteers with regular cycles and established ovulation by ultrasonography and serum progesterone concentrations were recruited from an out-patient clinic in a university hospital and asked to participate in the study. Transvaginal ultrasonography and serum oestradiol, progesterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) measurements were performed throughout the 7th and 12th 28 day treatment period. Desogestrel at a dose of 75 µg showed a significant inhibition of ovulation compared to 30 µg levonorgestrel (P < 0.001).

Key words: desogestrel/inhibition of ovulation/levonorgestrel/progestogen-only contraceptives

3 To whom correspondence should be addressed


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