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Human Reproduction, Vol. 14, No. 5, 1157-1159, May 1999
© 1999 European Society of Human Reproduction and Embryology

Human albumin enhances expression of vascular endothelial growth factor in cultured human luteinizing granulosa cells: importance in ovarian hyperstimulation syndrome

Nicola Doldi1, Alessandro Destefani, Alessandra Gessi, Donatella Grossi and Augusto Ferrari

Department of Obstetrics and Gynecology, University of Milan, H San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy 1 To whom correspondence should be addressed

Ovarian hyperstimulation syndrome (OHSS) is a severe complication of ovarian stimulation for assisted reproductive techniques. Clinical manifestations are massive extravascular fluid accumulation and haemoconcentration. Vascular endothelial growth factor (VEGF) has been demonstrated to mediate the development of OHSS. Intravenous albumin at the time of oocyte aspiration has been suggested as an effective prophylactic treatment against the occurrence of severe OHSS. Here it is reported that in cultured human luteinizing granulosa cells, VEGF mRNA expression was enhanced by human albumin and maximum expression was observed in cultured granulosa cells obtained from patients with serum oestradiol concentrations >2000 pg/ml on the day of human chorionic gonadotrophin injection (P < 0.05).

Key words: albumin/granulosa cells/ovarian hyperstimulation syndrome/vascular endothelial growth factor


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