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Human Reproduction, Vol. 14, No. 6, 1440-1444, June 1999
© 1999 European Society of Human Reproduction and Embryology

Effect of prednisolone on serum and follicular fluid androgen concentrations in women with polycystic ovary syndrome undergoing in-vitro fertilization

Margareta Fridström1,3, Kjell Carlström1, Peter Sjöblom1 and Torbjörn Hillensjö2

1 Department of Clinical Science, Division of Obstetrics and Gynecology, Huddinge University Hospital, Stockholm, and 2 Fertility Center Scandinavia, Carlanderska Hospital, Göteborg

Increased androgen concentrations are thought to be detrimental to oocyte quality and reproductive potential. Adjuvant treatment with glucocorticoids has been tried to suppress androgens in women undergoing infertility treatment. In the present study 20 infertile women with polycystic ovary syndrome were prospectively randomized in a placebo-controlled study to receive either placebo or prednisolone 10 mg at night, during standard in-vitro fertilization (IVF) treatment. Serum samples for assays of gonadotrophins, steroids and sex hormone-binding globulin (SHBG) were collected before treatment, at down-regulation, and at oocyte retrieval. Up to five follicles in each ovary were analysed separately regarding follicular fluid and oocytes, the rest according to the clinic's routines. In the placebo group, serum dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEA-S) did not change between down-regulation and oocyte retrieval, whereas adjuvant prednisolone resulted in a significant decrease. In follicular fluid, adjuvant prednisolone resulted in significantly lower concentrations of DHEA-S as compared to placebo, no other significant differences were found. No significant differences were found in embryo characteristics or pregnancy rates between the groups.

Key words: : androgens/follicular fluid/glucocorticoids/in-vitro fertilization/PCOS

3 To whom correspondence should be addressed at: IVF unit, K 57, Department of Clinical Science, Division of Obstetrics and Gynecology, Huddinge University Hospital, S-141 86 Huddinge, Sweden


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