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Human Reproduction, Vol. 14, No. 6, 1470-1472, June 1999
© 1999 European Society of Human Reproduction and Embryology

Adhesion preventive effect of hyaluronic acid after intraperitoneal surgery in mice

Tomio Sawada1, Kiyoshi Hasegawa, Kazuhiko Tsukada and Seiji Kawakami

1 Department of Obstetrics and Gynecology, Fujita Health University, School of Medicine, 1–98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, Japan 470-1192

Prevention of intraperitoneal adhesion after gynaecological surgery is essential for maintaining postoperative fertility. In this study, the adhesion prevention effect was examined of a hyaluronic acid (HA) solution obtained from the fermentation method and having a molecular weight of 1.9x106 with high viscosity. Laparotomy was conducted on female mice 7 weeks old, whose menstrual periods were synchronized by pregnant mare serum gonadotrophin (PMSG) to injure the uterine horn surface. Intraperitoneal adhesions were favourably formed in 91.7% of cases induced with iodine abrasion, compared with 50% induced by electrosurgery. Intraperitoneal administration of HA was evaluated for its effect on the prevention of adhesions made by iodine abrasion. Adhesion prevention effects of HA were observed at concentrations of 0.3, 0.5, 0.75 and 1.0%, among which the most pronounced effect was with the use of a 0.3% solution (92.3% of cases). Compared with the control group adhesion score of 2.0 ± 0.8, significant decreases in adhesion scores were observed at all concentrations. HA with a molecular weight of 1.9x106 was recognized to have a definitive prevention effect on postoperative adhesions in mice after laparotomy and is considered to be a prospective material for future clinical use.

Key words: adhesion/adhesion prevention/hyaluronic acid/murine uterine horn model/reproductive surgery

1 To whom correspondence should be addressed


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T. Sawada, K. Tsukada, K. Hasegawa, Y. Ohashi, Y. Udagawa, and V. Gomel
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