Human Reproduction, Vol. 14, No. 7, 1760-1764,
July 1999
© 1999 European Society of Human Reproduction and Embryology
Perinatal and obstetric outcomes of donor insemination using cryopreserved semen in Victoria, Australia
1 Perinatal Data Collection Unit, Department of Human Services, Victoria 3001, 2 Centre for the Study of Mothers' & Children's Health, La Trobe University, Victoria 3053, 3 Prince Henry's Institute of Medical Research, Victoria 3168 and 4 Monash IVF, Victoria 3121, Australia
This study compared the perinatal and obstetric outcomes of 1552 donor insemination pregnancies in Victoria, Australia, with a control group of 7717 normally conceived pregnancies from the general population. Data on the outcomes of pregnancies of at least 20 weeks gestation, for both groups, were obtained from the same population-based birth registry. The study showed that there were no significant differences between the donor insemination and control groups in the incidence of preterm birth, low birthweight, multiple birth, perinatal death and birth defects, or in the sex ratio. Pregnancies conceived by donor insemination were significantly more likely than controls to have an induced labour (OR = 1.6, 95% CI 1.4–1.8), a forceps delivery (OR = 1.5, 95% CI 1.3–1.8) and/or a Caesarean section (OR = 1.6, 95% CI 1.4–1.9) and to develop pre-eclampsia (OR = 1.4, 95% CI 1.2–1.8) after adjusting for maternal age, multiple birth, parity and presentation. Reasons for the higher rate of induced and operative deliveries are not clear. Overall, the study's findings are reassuring for couples considering infertility treatment with donor insemination. The study illustrates the importance of complete follow-up in studies of pregnancy outcomes after assisted conception and the use of appropriate population-based control groups with comparable ascertainment of outcomes.
Key words: birth defects/donor insemination/follow-up/pregnancy outcomes
5 To whom correspondence should be addressed at: Centre for the Study of Mothers' & Children's Health, La Trobe University, Locked Bag 6, Post Office, Carlton South, Victoria 3053, Australia
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