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Human Reproduction, Vol. 14, No. 7, 1771-1772, July 1999
© 1999 European Society of Human Reproduction and Embryology

Pregnancies after activated oocyte transfer: a new option for infertility treatment

Brian Dale1,2,5, Agnese Fiorentino1, Renato De Stefano3, Loredana Di Matteo1, Maria laura De Simone1, Martin Wilding2 and Fulvio Zullo4

1 Biologia della Riproduzione, Clinica Villa del Sole, Via Manzoni, 15, Naples 80123, 2 Stazione Zoologica `Anton Dohrn', Villa Comunale, 1, 80121 Naples, 3 Endogyn Service, Naples and 4 Institute of Gynecological and Pediatric Sciences, University of Catanzaro, Italy

In this preliminary report, we describe a new technique involving the same-day transfer of activated oocytes to the uterus after intracytoplasmatic sperm injection (ICSI). The technique, termed activated oocyte transfer (AOT), offered to 19 couples, yielded a pregnancy rate per cycle of about 30%, equivalent to traditional in-vitro fertilization (IVF) and ICSI in a laboratory setting. AOT is performed 4 h after oocyte retrieval, permitting the patient to undergo treatment as an out-patient procedure.

Key words: activated oocyte transfer/human in-vitro fertilization/ICSI/male infertility/out-patient procedure

5 To whom correspondence should be addressed at: Biologia della Riproduzione, Clinica Villa del Sole, Via Manzoni, 15, Naples 80123, Italy


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