Human Reproduction, Vol. 14, No. 7, 1896-1902,
July 1999
© 1999 European Society of Human Reproduction and Embryology
Danish National In-Vitro Fertilization Registry 1994 and 1995: a controlled study of births, malformations and cytogenetic findings
1 The Fertility Clinic, Rigshospitalet, 2100 Copenhagen Ø, 2 The National Board of Health, 4th Office, Amaliegade 13, Postbox 2020, 1012 Copenhagen K and 3 The Danish Fertility Society, 4 The Fertility Clinic, Odense University Hospital, 5000 Odense C, Denmark
This paper reports data from the Danish in-vitro fertilization (IVF) registry from 1994 to 1995 including data on treatments and the results of these (perinatal outcome, cytogenetic findings and fetal malformations) in comparison with a control group matched for maternal age, parity, multiplicity and year of birth. There were 1756 deliveries of 2245 children (24.3% twins, 1.8% triplets). The rate of prematurity among IVF children was 23.8% (NS) [singletons 7.3% (P < 0.05), twins 41.2% and triplets 93.5%], 23.6% weighed <2500 g [singletons 7% (P < 0.05), twins 42.2% and triplets 87.1%]. The perinatal mortality rate was 21.8 in the study group compared to 17.4 in the control group (NS). In total, 13.2% of all clinical pregnancies and 15.4% of the pregnancies that resulted in a delivery had a prenatal genetic examination. Of all examined, 3.5% had an abnormal karyotype. In total, 107 (4.8%) children in the study group and 103 (4.6%) in the control group were born with malformations (NS), compared to 2.8% in the background population. Our results indicate that it is the characteristics of the patients and multiplicity of pregnancy, rather than the assisted reproductive technology that determines the fetal risks of IVF pregnancies compared to the background population.
Key words: assisted reproduction/congenital malformation/fetal karyotype/National Registry/perinatal data
5 To whom correspondence should be addressed
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  U.-B. Wennerholm, V. Soderstrom-Anttila, C. Bergh, K. Aittomaki, J. Hazekamp, K.-G. Nygren, A. Selbing, and A. Loft Children born after cryopreservation of embryos or oocytes: a systematic review of outcome data Hum. Reprod., September 1, 2009; 24(9): 2158 - 2172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hansen, L. Colvin, B. Petterson, J. J. Kurinczuk, N. de Klerk, and C. Bower Twins born following assisted reproductive technology: perinatal outcome and admission to hospital Hum. Reprod., September 1, 2009; 24(9): 2321 - 2331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Belva, S. Henriet, E. Van den Abbeel, M. Camus, P. Devroey, J. Van der Elst, I. Liebaers, P. Haentjens, and M. Bonduelle Neonatal outcome of 937 children born after transfer of cryopreserved embryos obtained by ICSI and IVF and comparison with outcome data of fresh ICSI and IVF cycles Hum. Reprod., October 1, 2008; 23(10): 2227 - 2238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Boulet, L. A. Schieve, A. Nannini, C. Ferre, O. Devine, B. Cohen, Z. Zhang, V. Wright, and M. Macaluso Perinatal outcomes of twin births conceived using assisted reproduction technology: a population-based study Hum. Reprod., August 1, 2008; 23(8): 1941 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Axer-Siegel, Z. Herscovici, S. Davidson, N. Linder, I. Sherf, and M. Snir Early Structural Status of the Eyes of Healthy Term Neonates Conceived by In Vitro Fertilization or Conceived Naturally Invest. Ophthalmol. Vis. Sci., December 1, 2007; 48(12): 5454 - 5458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hansen, E. Sullivan, A.M. Jequier, P. Burton, S. Junk, J. Yovich, and C. Bower Practitioner reporting of birth defects in children born following assisted reproductive technology: Does it still have a role in surveillance of birth defects? Hum. Reprod., February 1, 2007; 22(2): 516 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Mau Kai, K. M. Main, A. Nyboe Andersen, A. Loft, M. Chellakooty, N. E. Skakkebaek, and A. Juul Serum Insulin-Like Growth Factor-I (IGF-I) and Growth in Children Born after Assisted Reproduction J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4352 - 4360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-M. Park, R. Mathur, and G. C S Smith Congenital anomalies after treatment for infertility. BMJ, September 30, 2006; 333(7570): 665 - 666. [Full Text] [PDF]
|
|
|
|
|
|
J. L. Zhu, O. Basso, C. Obel, C. Bille, and J. Olsen Infertility, infertility treatment, and congenital malformations: Danish national birth cohort BMJ, September 30, 2006; 333(7570): 679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.K. Ludwig, A. Katalinic, V. Steinbicker, K. Diedrich, and M. Ludwig Antenatal care in singleton pregnancies after ICSI as compared to spontaneous conception: data from a prospective controlled cohort study in Germany Hum. Reprod., March 1, 2006; 21(3): 713 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pinborg IVF/ICSI twin pregnancies: risks and prevention Hum. Reprod. Update, November 1, 2005; 11(6): 575 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. De Sutter, L. Veldeman, P. Kok, N. Szymczak, J. Van der Elst, and M. Dhont Comparison of outcome of pregnancy after intra-uterine insemination (IUI) and IVF Hum. Reprod., June 1, 2005; 20(6): 1642 - 1646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Axer-Siegel, D. Bourla, L. Sirota, D. Weinberger, and M. Snir Ocular Growth in Premature Infants Conceived by In Vitro Fertilization versus Natural Conception Invest. Ophthalmol. Vis. Sci., April 1, 2005; 46(4): 1163 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Lidegaard, A. Pinborg, and A. N. Andersen Imprinting diseases and IVF: Danish National IVF cohort study Hum. Reprod., April 1, 2005; 20(4): 950 - 954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hansen, C. Bower, E. Milne, N. de Klerk, and J. J.Kurinczuk Assisted reproductive technologies and the risk of birth defects--a systematic review Hum. Reprod., February 1, 2005; 20(2): 328 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bergh Single embryo transfer: a mini-review Hum. Reprod., February 1, 2005; 20(2): 323 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bonduelle, U.-B. Wennerholm, A. Loft, B.C. Tarlatzis, C. Peters, S. Henriet, C. Mau, A. Victorin-Cederquist, A. Van Steirteghem, A. Balaska, et al. A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception Hum. Reprod., February 1, 2005; 20(2): 413 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Thurin, J. Hausken, T. Hillensjo, B. Jablonowska, A. Pinborg, A. Strandell, and C. Bergh Elective Single-Embryo Transfer versus Double-Embryo Transfer in in Vitro Fertilization N. Engl. J. Med., December 2, 2004; 351(23): 2392 - 2402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.D. Biggers and M.C. Summers When to avoid creating surplus human embryos Hum. Reprod., November 1, 2004; 19(11): 2457 - 2459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pinborg, A. Loft, L. Schmidt, G. Greisen, S. Rasmussen, and A. N. Andersen Neurological sequelae in twins born after assisted conception: controlled national cohort study BMJ, August 7, 2004; 329(7461): 311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pinborg, A. Loft, S. Ziebe, and A. Nyboe Andersen What is the most relevant standard of success in assisted reproduction?: Is there a single 'parameter of excellence'? Hum. Reprod., May 1, 2004; 19(5): 1052 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Schieve and M. A. Reynolds What is the most relevant standard of success in assisted reproduction?: Challenges in measuring and reporting success rates for assisted reproductive technology treatments: What is optimal? Hum. Reprod., April 1, 2004; 19(4): 778 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pinborg, A. Loft, S. Rasmussen, L. Schmidt, J. Langhoff-Roos, G. Greisen, and A. Nyboe Andersen Neonatal outcome in a Danish national cohort of 3438 IVF/ICSI and 10 362 non-IVF/ICSI twins born between 1995 and 2000 Hum. Reprod., February 1, 2004; 19(2): 435 - 441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pinborg, A. Loft, L. Schmidt, and A. N. Andersen Morbidity in a Danish National cohort of 472 IVF/ICSI twins, 1132 non-IVF/ICSI twins and 634 IVF/ICSI singletons: health-related and social implications for the children and their families Hum. Reprod., June 1, 2003; 18(6): 1234 - 1243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. G. Hughes Stimulated intra-uterine insemination is not a natural choice for the treatment of unexplained subfertility: 'Effective treatment' or 'not a natural choice'? Hum. Reprod., May 1, 2003; 18(5): 912 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Reefhuis, M. A. Honein, G. M. Shaw, and P. A. Romitti Fertility Treatments and Craniosynostosis: California, Georgia, and Iowa, 1993-1997 Pediatrics, May 1, 2003; 111(5): 1163 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pinborg, A. Loft, L. Schmidt, and A. N. Andersen Attitudes of IVF/ICSI-twin mothers towards twins and single embryo transfer Hum. Reprod., March 1, 2003; 18(3): 621 - 627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Boerrigter, J. J. de Bie, B. M.J.L. Mannaerts, B. P. van Leeuwen, and D. P.J. Passier-Timmermans Obstetrical and neonatal outcome after controlled ovarian stimulation for IVF using the GnRH antagonist ganirelix Hum. Reprod., August 1, 2002; 17(8): 2027 - 2034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Anthony, S.E. Buitendijk, C.A. Dorrepaal, K. Lindner, D.D.M. Braat, and A.L. den Ouden Congenital malformations in 4224 children conceived after IVF Hum. Reprod., August 1, 2002; 17(8): 2089 - 2095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Klemetti, M. Gissler, and E. Hemminki Comparison of perinatal health of children born from IVF in Finland in the early and late 1990s Hum. Reprod., August 1, 2002; 17(8): 2192 - 2198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Isaksson, M. Gissler, and A. Tiitinen Obstetric outcome among women with unexplained infertility after IVF: a matched case-control study Hum. Reprod., July 1, 2002; 17(7): 1755 - 1761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Koivurova, A.-L. Hartikainen, M. Gissler, E. Hemminki, U. Sovio, and M.-R. Jarvelin Neonatal outcome and congenital malformations in children born after in-vitro fertilization Hum. Reprod., May 1, 2002; 17(5): 1391 - 1398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Schieve, S. F. Meikle, C. Ferre, H. B. Peterson, G. Jeng, and L. S. Wilcox Low and Very Low Birth Weight in Infants Conceived with Use of Assisted Reproductive Technology N. Engl. J. Med., March 7, 2002; 346(10): 731 - 737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bonduelle, I. Liebaers, V. Deketelaere, M.-P. Derde, M. Camus, P. Devroey, and A. Van Steirteghem Neonatal data on a cohort of 2889 infants born after ICSI (1991-1999) and of 2995 infants born after IVF (1983-1999) Hum. Reprod., March 1, 2002; 17(3): 671 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Golombok, A. Brewaeys, M.T. Giavazzi, D. Guerra, F. MacCallum, and J. Rust The European study of assisted reproduction families: the transition to adolescence Hum. Reprod., March 1, 2002; 17(3): 830 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Olivennes, B. Mannaerts, M. Struijs, M. Bonduelle, and P. Devroey Perinatal outcome of pregnancy after GnRH antagonist (ganirelix) treatment during ovarian stimulation for conventional IVF or ICSI: a preliminary report Hum. Reprod., August 1, 2001; 16(8): 1588 - 1591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ericson and B. Kallen Congenital malformations in infants born after IVF: a population-based study Hum. Reprod., March 1, 2001; 16(3): 504 - 509. [Abstract] [Full Text] [PDF]
|
|