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Human Reproduction, Vol. 14, No. 9, 2381-2385, September 1999
© 1999 European Society of Human Reproduction and Embryology

Second-trimester maternal urine human chorionic gonadotrophin ß-core fragment concentrations in Asian pregnancies with fetal chromosomal abnormalities

Jenn J. Hsu1,4, Kevin Spencer2, Tai H. Hung1, T'sang T. Hsieh1 and Yung K. Soong3

1 Department of Obstetrics and Gynaecology, Taipei Chang Gung Memorial Hospital, Taipei, 2 The Endocrine Unit, Department of Clinical Biochemistry, Harold Wood Hospital, Romford, Essex, UK and 3 Lin-Kou Chang Gung Memorial Hospital, Tau-Young, Taiwan, ROC

The aim of this study was to investigate the second trimester concentrations of maternal urine human chorionic gonadotrophin ß-core fragment (HCGßcf) in Asian pregnanci2es with fetal chromosomal abnormalities. HCGßcf concentrations were analysed from 34 urine samples in chromosomally abnormal pregnancies, including 28 cases of Down's syndrome, one case of trisomy 18, and five cases of other chromosomal abnormalities (one mosaic deletion and four translocations), and in a cohort of 268 normal pregnancies receiving second trimester amniocentesis. Results were normalized to urine creatinine (Cr) concentration and converted to the multiple of the median (MOM) concentration for the appropriate gestation. The median HCGßcf MOM concentrations of Down's syndrome pregnancies (12.89) was significantly higher than that of normal pregnancies (1.06) (P < 0.00001). Wide variations of HCGßcf concentrations were observed in other chromosomally abnormal pregnancies. There were 18 of 28 (64%) Down's syndrome cases but one of five (20%) other chromosomally abnormal cases with HCGßcf concentrations above the 95th centile of the control values (8.22 MOM cut-off). These findings suggest that HCGßcf could be a potential marker in urine screening for fetal Down's syndrome in Asians.

Key words: chromosomal abnormalities/Down's syndrome/human chorionic gonadotrophin ß-core fragment/prenatal screening/urine

4 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital, 199, Tung-Hwa North Road, Taipei, Taiwan, Republic of China


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