Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kay, V.J.
Right arrow Articles by Irvine, D.S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kay, V.J.
Right arrow Articles by Irvine, D.S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 15, No. 1, 135-138, January 2000
© 2000 European Society of Human Reproduction and Embryology

Successful in-vitro fertilization pregnancy with spermatozoa from a patient with Kartagener's syndrome: Case Report

V.J. Kay1,3 and D.S. Irvine2

1 Department of Obstetrics and Gynaecology, Royal Infirmary of Edinburgh, 1 Lauriston Place, Edinburgh EH3 9EF and 2 MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, UK

This paper reports on the successful treatment by in-vitro fertilization (IVF) of a couple in whom the male partner had Kartagener's syndrome. His spermatozoa were severely asthenozoospermic with deficient dynein arms and disordered microtubular configuration. On computer-assisted sperm analysis (CASA) motile spermatozoa displayed straight non-progressive motility with minimal amplitude of lateral head displacement and none were hyperactivated. This is the first case report in which spermatozoa with axonemal disruption in a man with immotile cilia syndrome (ICS) have been shown to be able to penetrate the zona pellucida and fertilize oocytes. IVF may be a suitable treatment for certain variants of ICS.

Key words: dynein arm deficiency/immotile cilia syndrome/immotile spermatozoa/Kartagener's syndrome

3 To whom correspondence should be addressed


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Reproductive SciencesHome page
C. J. Lockwood, G. Krikun, M. Hickey, S. J. Huang, and F. Schatz
Decidualized Human Endometrial Stromal Cells Mediate Hemostasis, Angiogenesis, and Abnormal Uterine Bleeding
Reproductive Sciences, February 1, 2009; 16(2): 162 - 170.
[Abstract] [PDF]

Home page
 ReproductionHome page
N. B Morison, J. Zhang, T. J Kaitu'u-Lino, I. S Fraser, and L. A Salamonsen
The long-term actions of etonogestrel and levonorgestrel on decidualized and non-decidualized endometrium in a mouse model mimic some effects of progestogen-only contraceptives in women
Reproduction, January 1, 2007; 133(1): 309 - 321.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Peloggia, C. A. Petta, L. Bahamondes, M. Oliveira-Ribeiro, J. Zhang, and L. Salamonsen
Endometrial chemokines, uterine natural killer cells and mast cells in long-term users of the levonorgestrel-releasing intrauterine system
Hum. Reprod., May 1, 2006; 21(5): 1129 - 1134.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
M. Wahab, A.H. Taylor, J.H. Pringle, J. Thompson, and F. Al-Azzawi
Trimegestone differentially modulates the expression of matrix metalloproteinases in the endometrial stromal cell
Mol. Hum. Reprod., March 1, 2006; 12(3): 157 - 167.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. Weisberg, M. Hickey, D. Palmer, V. O'Connor, L.A. Salamonsen, J.K. Findlay, and I.S. Fraser
A pilot study to assess the effect of three short-term treatments on frequent and/or prolonged bleeding compared to placebo in women using Implanon
Hum. Reprod., January 1, 2006; 21(1): 295 - 302.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. L. Jones, N. B. Morison, N. J. Hannan, H. O.D. Critchley, and L. A. Salamonsen
Chemokine expression is dysregulated in the endometrium of women using progestin-only contraceptives and correlates to elevated recruitment of distinct leukocyte populations
Hum. Reprod., October 1, 2005; 20(10): 2724 - 2735.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
N. Rives, N. Mousset-Simeon, S. Mazurier, and B. Mace
Primary Flagellar Abnormality Is Associated With an Increased Rate of Spermatozoa Aneuploidy
J Androl, January 1, 2005; 26(1): 61 - 69.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
T. E. Curry Jr. and K. G. Osteen
The Matrix Metalloproteinase System: Changes, Regulation, and Impact throughout the Ovarian and Uterine Reproductive Cycle
Endocr. Rev., August 1, 2003; 24(4): 428 - 465.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A.J. Vincent, J. Zhang, A. Ostor, P.A.W. Rogers, B. Affandi, G. Kovacs, and L.A. Salamonsen
Decreased tissue inhibitor of metalloproteinase in the endometrium of women using depot medroxyprogesterone acetate: a role for altered endometrial matrix metalloproteinase/tissue inhibitor of metalloproteinase balance in the pathogenesis of abnormal uterine bleeding?
Hum. Reprod., May 1, 2002; 17(5): 1189 - 1198.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.