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Human Reproduction, Vol. 15, No. 1, 139-141, January 2000
© 2000 European Society of Human Reproduction and Embryology

A normal livebirth after intracytoplasmic sperm injection for globozoospermia without assisted oocyte activation: Case Report

S. Stone, F. O'Mahony, Y. Khalaf1, A. Taylor and P. Braude

Assisted Conception Unit, Guy's and St Thomas' Hospitals Trust, Lambeth Palace Road, London SE1 7EH, UK

The successful outcome of intracytoplasmic sperm injection (ICSI) with round-headed spermatozoa (globozoospermia) is reported. A couple with infertility secondary to globozoospermia received ICSI treatment. Fertilization, cleavage and pregnancy outcomes were recorded. This couple experienced 40, 10 and 42% fertilization rates after ICSI in their first, second and third cycles respectively. Pregnancy did not occur in the first or second cycle but was successfully achieved after the third ICSI cycle. It is concluded that current ICSI procedures may overcome the infertility associated with globozoospermia and result in normal healthy livebirth without assisted oocyte activation.

Key words: fertilization/globozoospermia/intracytoplasmic sperm injection/male factor infertility

1 To whom correspondence should be addressed


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