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Human Reproduction, Vol. 15, No. 1, 224-226, January 2000
© 2000 European Society of Human Reproduction and Embryology

Evaluation of low serum vitamin B12 in the non-anaemic pregnant patient

J. Pardo1,3, Y. Peled1, J. Bar1, M. Hod1, B.A. Sela2, Z.Ben Rafael1 and R. Orvieto1

1 Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, and 2 Institute of Chemical Pathology, Sheba Medical Center, Tel Hashomer, Israel

Low serum vitamin B12 concentrations in pregnancy may not indicate true megaloblastic anaemia. In the present study we compared biochemical indices of vitamin B12 deficiency (serum homocysteine and urine methylmalonic acid) in non-anaemic pregnant women with and without low serum vitamin B12 concentrations. The groups were matched for age, parity and gestational age. No differences were found, and all values were within normal range. These results suggest that the measurement of low serum B12 concentrations in pregnant women should be followed by analysis at the biochemical level before vitamin B12 injections are started.

Key words: homocysteine/methylmalonic acid/pregnancy/vitamin B12

3 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Rabin Medical Center (Beilinson Campus), Petah Tiqva 49100, Israel


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