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Human Reproduction, Vol. 15, No. 1, 8-10, January 2000
© 2000 European Society of Human Reproduction and Embryology

Debate Continued

Severe OHSS: How many cases are preventable?

P. E. Egbase1

IVF Centre, Maternity Hospital, Kuwait City, Kuwait and Department of Obstetrics & Gynaecology, St Bartholomew's & The Royal London School of Medicine & Dentistry, Royal London Hospital, Whitechapel, London, E1 1BB, UK

During 1995, >50 000 cycles of ovarian hyperstimulation for the purpose of in-vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) or gamete intra-Fallopian transfer (GIFT) were reported in the World Collaborative Report on IVF (1997) and it is believed that equally as many cycles of ovulation induction are undertaken annually. As the overall incidence of clinically relevant ovarian hyperstimulation syndrome (OHSS) occurs in up to 10% of cycles, some of which (0.5–2%) are life-threatening (Forman et al., 1990Go), it is important for all clinicians, not only infertility specialists, to be aware of strategies in its prevention.

OHSS is iatrogenic, and thus places an overwhelming onus on the clinician to avert it if at all possible. But how many cases are actually preventable without compromising the patient's chances of successful outcome of the intended treatment? A balance between optimum ovarian stimulation and successful treatment outcome in the absence of severe . . . [Full Text of this Article]

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