Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Murray, R.D.
Right arrow Articles by Conway, G.S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murray, R.D.
Right arrow Articles by Conway, G.S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 15, No. 1, 86-88, January 2000
© 2000 European Society of Human Reproduction and Embryology

Clinical presentation of PCOS following development of an insulinoma: Case Report

R.D. Murray1, R.M. Davison1, R.C. Russell2 and G.S. Conway1,3

1 Department of Endocrinology, and 2 Department of Surgery, The Middlesex Hospital, London WIN 8AA, UK

A 24 year old woman presented with a prolonged clinical history of fasting and exertional hypoglycaemia, and was subsequently diagnosed with an insulinoma. Concurrent symptoms of oligomenorrhoea and hyperandrogenism of similar duration were noted. Biochemically, hyperinsulinaemia was observed in association with a raised serum luteinizing hormone (LH), raised testosterone and androstendione concentrations. Surgical removal of the insulinoma resulted in resolution of the clinical and biochemical features of the polycystic ovarian syndrome (PCOS) but minimal change was observed in the ovarian ultrasound appearances. This case demonstrates the role of insulin in mediating the hypersecretion of both LH and androgens in women with polycystic ovaries. We suggest that hyperinsulinaemia converted occult `polycystic ovaries' to become clinically manifest as `polycystic ovary syndrome'. This paradigm has clear implications for women with insulin dependent diabetes mellitus who presumably have systemic hyperinsulinaemia.

Key words: hirsutism/hyperinsulinaemia/insulinoma/PCOS

To whom correspondence should be addressed at: The Cobbold Laboratories, The Middlesex Hospital, Mortimer Street, London W1N 8AA, UK


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 FASEB J.Home page
G. L. Wright, I. G. Maroulakou, J. Eldridge, T. L. Liby, V. Sridharan, P. N. Tsichlis, and R. C. Muise-Helmericks
VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase
FASEB J, September 1, 2008; 22(9): 3264 - 3275.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. Codner and H. F. Escobar-Morreale
Hyperandrogenism and Polycystic Ovary Syndrome in Women with Type 1 Diabetes Mellitus
J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1209 - 1216.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
L.J.A.M. Jacobs, G. de Wert, J.P.M. Geraedts, I.F.M. de Coo, and H.J.M. Smeets
The transmission of OXPHOS disease and methods to prevent this
Hum. Reprod. Update, March 1, 2006; 12(2): 119 - 136.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
P. May-Panloup, M-F. Chretien, F. Savagner, C. Vasseur, M. Jean, Y. Malthiery, and P. Reynier
Increased sperm mitochondrial DNA content in male infertility
Hum. Reprod., March 1, 2003; 18(3): 550 - 556.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. Diez-Sanchez, E. Ruiz-Pesini, A. C. Lapena, J. Montoya, A. Perez-Martos, J. A. Enriquez, and M. J. Lopez-Perez
Mitochondrial DNA Content of Human Spermatozoa
Biol Reprod, January 1, 2003; 68(1): 180 - 185.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. M. Ricken and C. Viebahn
Stage-Specific Expression of the Mitochondrial Germ Cell Epitope PG2 During Postnatal Differentiation of Rabbit Germ Cells
Biol Reprod, July 1, 2002; 67(1): 196 - 203.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.