Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow An erratum has been published
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (42)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Lévy, D. P.
Right arrow Articles by Rosenwaks, Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lévy, D. P.
Right arrow Articles by Rosenwaks, Z.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 15, No. 11, 2258-2265, November 2000
© 2000 European Society of Human Reproduction and Embryology

The role of LH in ovarian stimulation

Exogenous LH: let's design the future

Delphine P. Lévy1, José M. Navarro1, Glenn L. Schattman1,2, Owen K. Davis1 and Zev Rosenwaks1

1 The Center For Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, USA

Historically, follicular stimulation protocols have included both FSH and LH in an attempt to mimic the physiology of normal human folliculogenesis. However, many recent gonadotrophin administration regimens have completely eliminated LH bioactivity. The importance and the amount of LH necessary for optimal follicular stimulation has been a topic of debate. Several recent studies have added to our understanding of the actions of androgens, oestrogens, gonadotrophins, and insulin on the follicle–oocyte unit, allowing a less speculative approach. Moreover, the availability of human gonadotrophins synthesized by recombinant DNA technology and gonadotrophin-releasing hormone (GnRH) antagonists, should soon permit a precise in-vivo assessment and re-evaluation of the historical 2-cell, two-gonadotrophin hypothesis. These pharmacological tools may also provide essential insights into the physiological roles of FSH and LH in human follicular development and oocyte maturation. The recombinant gonadotrophins give clinicians the unique opportunity to tailor ovarian stimulation regimens according to the patient's medical history, in an effort both to maximize oocyte yield and to improve oocyte quality.

Key words: folliculogenesis/IVF/LH/ovarian stimulation

This debate was previously published on Webtrack, July 27, 2000

2 To whom correspondence should be addressed at: The Center For Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York, USA. E-mail: glschatt{at}mail.med.cornell.edu


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 EndocrinologyHome page
L. M. Garone, E. Ammannati, T. S. Brush, D. J. Fischer, E. G. Tos, J. Luo, K. L. Altobello, C. Ciampolillo, T. M. Ihley, E. Kurosawa, et al.
Biological Properties of a Novel Follicle-Stimulating Hormone/Human Chorionic Gonadotropin Chimeric Gonadotropin
Endocrinology, September 1, 2006; 147(9): 4205 - 4212.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
N. S. Macklon, R. L. Stouffer, L. C. Giudice, and B. C. J. M. Fauser
The Science behind 25 Years of Ovarian Stimulation for in Vitro Fertilization
Endocr. Rev., April 1, 2006; 27(2): 170 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Bjercke, P. Fedorcsak, T. Abyholm, R. Storeng, G. Ertzeid, N. Oldereid, A. Omland, and T. Tanbo
IVF/ICSI outcome and serum LH concentration on day 1 of ovarian stimulation with recombinant FSH under pituitary suppression
Hum. Reprod., September 1, 2005; 20(9): 2441 - 2447.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G. Griesinger, A. Schultze-Mosgau, K. Dafopoulos, A. Schroeder, A. Schroer, S. von Otte, D. Hornung, K. Diedrich, and R. Felberbaum
Recombinant luteinizing hormone supplementation to recombinant follicle-stimulating hormone induced ovarian hyperstimulation in the GnRH-antagonist multiple-dose protocol
Hum. Reprod., May 1, 2005; 20(5): 1200 - 1206.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G. De Placido, C. Alviggi, A. Perino, I. Strina, F. Lisi, A. Fasolino, R. De Palo, A. Ranieri, N. Colacurci, A. Mollo, et al.
Recombinant human LH supplementation versus recombinant human FSH (rFSH) step-up protocol during controlled ovarian stimulation in normogonadotrophic women with initial inadequate ovarian response to rFSH. A multicentre, prospective, randomized controlled trial
Hum. Reprod., February 1, 2005; 20(2): 390 - 396.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E.M. Kolibianakis, K. Zikopoulos, J. Schiettecatte, J. Smitz, H. Tournaye, M. Camus, A.C. Van Steirteghem, and P. Devroey
Profound LH suppression after GnRH antagonist administration is associated with a significantly higher ongoing pregnancy rate in IVF
Hum. Reprod., November 1, 2004; 19(11): 2490 - 2496.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. U. Meysing, H. Kanasaki, G. Y. Bedecarrats, J. S. Acierno Jr., P. M. Conn, K. A. Martin, S. B. Seminara, J. E. Hall, W. F. Crowley Jr., and U. B. Kaiser
GNRHR Mutations in a Woman with Idiopathic Hypogonadotropic Hypogonadism Highlight the Differential Sensitivity of Luteinizing Hormone and Follicle-Stimulating Hormone to Gonadotropin-Releasing Hormone
J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3189 - 3198.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
F.-J. Huang, K.-C. Lan, F.-T. Kung, M.-Y. Tsai, C.-Y. Chang, H.-W. Huang, Y.-C. Lin, and S.-Y. Chang
Human cumulus-free oocyte maturational profile and in vitro developmental potential after stimulation with recombinant versus urinary FSH
Hum. Reprod., February 1, 2004; 19(2): 306 - 315.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. Penarrubia, F. Fabregues, M. Creus, D. Manau, R. Casamitjana, M. Guimera, F. Carmona, J. A. Vanrell, and J. Balasch
LH serum levels during ovarian stimulation as predictors of ovarian response and assisted reproduction outcome in down-regulated women stimulated with recombinant FSH
Hum. Reprod., December 1, 2003; 18(12): 2689 - 2697.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. Haywood, N. Tymchenko, J. Spaliviero, A. Koch, M. Jimenez, J. Gromoll, M. Simoni, V. Nordhoff, D. J. Handelsman, and C. M. Allan
An Activated Human Follicle-Stimulating Hormone (FSH) Receptor Stimulates FSH-Like Activity in Gonadotropin-Deficient Transgenic Mice
Mol. Endocrinol., November 1, 2002; 16(11): 2582 - 2591.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. Matorras and F. J. Rodriguez-Escudero
Bye-bye urinary gonadotrophins?: The use of urinary gonadotrophins should be discouraged
Hum. Reprod., July 1, 2002; 17(7): 1675 - 1675.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Filicori, G. E. Cognigni, C. Tabarelli, P. Pocognoli, S. Taraborrelli, D. Spettoli, and W. Ciampaglia
Stimulation and Growth of Antral Ovarian Follicles by Selective LH Activity Administration in Women
J. Clin. Endocrinol. Metab., March 1, 2002; 87(3): 1156 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. Balasch
The potential value of mid-follicular phase LH
Hum. Reprod., February 1, 2002; 17(2): 518 - 520.
[Full Text] [PDF]

Home page
 Biol. Reprod.Home page
P. Blondin, D. Bousquet, H. Twagiramungu, F. Barnes, and M.-A. Sirard
Manipulation of Follicular Development to Produce Developmentally Competent Bovine Oocytes
Biol Reprod, January 1, 2002; 66(1): 38 - 43.
[Abstract] [Full Text]

Home page
 Hum ReprodHome page
G. De Placido, A. Mollo, C. Alviggi, I. Strina, M. T. Varricchio, A. Ranieri, N. Colacurci, A. Tolino, and M. Wilding
Rescue of IVF cycles by HMG in pituitary down-regulated normogonadotrophic young women characterized by a poor initial response to recombinant FSH
Hum. Reprod., September 1, 2001; 16(9): 1875 - 1879.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. Balasch, E. Vidal, J. Penarrubia, R. Casamitjana, F. Carmona, M. Creus, F. Fabregues, and J. A. Vanrell
Suppression of LH during ovarian stimulation: analysing threshold values and effects on ovarian response and the outcome of assisted reproduction in down-regulated women stimulated with recombinant FSH
Hum. Reprod., August 1, 2001; 16(8): 1636 - 1643.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Filicori, G. L. Schattman, D. Levy, and J. Navarro
LH and ovulation induction
Hum. Reprod., April 1, 2001; 16(4): 803 - 804.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.