Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (12)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kol, S.
Right arrow Articles by Itskovitz-Eldor, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kol, S.
Right arrow Articles by Itskovitz-Eldor, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 15, No. 11, 2266-2267, November 2000
© 2000 European Society of Human Reproduction and Embryology

Severe OHSS

Yes, there is a strategy to prevent it!

S. Kol1,3 and J. Itskovitz-Eldor2

1 Department of Obstetrics and Gynecology, Rambam Medical Center, and 2 Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, 31096, Israel

Effective measures to prevent ovarian hyperstimulation syndrome (OHSS) remain controversial. It became almost `common knowledge' that there is no strategy that may completely prevent OHSS. Extensive clinical experience (albeit not derived from prospective randomized studies) clearly documents the ability of a single administration of gonadotrophin-releasing hormone (GnRH) agonist to effectively trigger ovulation, while completely eliminating any threat of clinically significant OHSS. This strategy cannot be used if the pituitary is down-regulated (as is the case in most assisted reproductive cycles today), however, the newly-introduced GnRH antagonists open new opportunities for implementing this strategy, since the pituitary preserves its responsiveness to GnRH agonists. Combining GnRH antagonist-based ovarian stimulation (particularly in `high responders'), with GnRH agonist-driven ovulation triggering will make severe OHSS a disease of the past in assisted reproduction.

Key words: GnRH agonist/OHSS/ovulation induction

3 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Rambam Medical Center, Technion – Israel Institute of Technology, Haifa 31096, Israel. E-mail: skol{at}rambam.health.gov.il

This debate was previously published on Webtrack, July 31, 2000


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
P. Humaidan, E.G. Papanikolaou, and B.C. Tarlatzis
GnRHa to trigger final oocyte maturation: a time to reconsider
Hum. Reprod., October 1, 2009; 24(10): 2389 - 2394.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G. Griesinger, S. von Otte, A. Schroer, A.K. Ludwig, K. Diedrich, S. Al-Hasani, and A. Schultze-Mosgau
Elective cryopreservation of all pronuclear oocytes after GnRH agonist triggering of final oocyte maturation in patients at risk of developing OHSS: a prospective, observational proof-of-concept study
Hum. Reprod., May 1, 2007; 22(5): 1348 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
G. Griesinger, K. Diedrich, P. Devroey, and E.M. Kolibianakis
GnRH agonist for triggering final oocyte maturation in the GnRH antagonist ovarian hyperstimulation protocol: a systematic review and meta-analysis
Hum. Reprod. Update, March 1, 2006; 12(2): 159 - 168.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Kol
Prediction of ovarian hyperstimulation syndrome: why predict if we can prevent!
Hum. Reprod., July 1, 2003; 18(7): 1557 - 1558.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Kol and O.-S. Tang
Should we explore OHSS full clinical scope?...
Hum. Reprod., March 1, 2001; 16(3): 595 - 596.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.