Human Reproduction, Vol. 15, No. 11, 2297-2301,
November 2000
© 2000 European Society of Human Reproduction and Embryology
Dynamic assays of inhibin B and oestradiol following buserelin acetate administration as predictors of ovarian response in IVF
1 IVF Unit, Department of Reproductive Medicine and Science 2 Department of Paediatrics, Obstetrics and Gynaecology and 3 Department of Clinical Chemistry, Imperial College School of Medicine, Hammersmith Hospital, London, UK
The study was designed to examine whether dynamic measurements of inhibin B and oestradiol following single administration of buserelin acetate were correlated with the ovarian response to stimulation in IVF. A total of 37 patients undergoing IVF treatment was studied when the long protocol was started in the early follicular phase. Blood samples were taken twice: on day 2 of the menstrual cycle, before the first s.c. administration of buserelin acetate 0.5 mg and on day 3, 24 h later. Inhibin B and oestradiol concentrations were compared with the ovarian response to stimulation. The ovarian response was defined in two ways: `number of oocytes/total recombinant (r) follicle stimulating hormone (FSH) dose'; and `square-root (number of follicles/total rFSH dose)'. The following measurements were highly correlated with the ovarian response to stimulation: increase in oestradiol (day 3–day 2 oestradiol concentration) [correlation coefficient (r) = 0.68, P < 0.0001] and sum of inhibin B (day 2 + day 3 inhibin B concentrations) (r = 0.6, P < 0.0001). Age and basal concentrations of FSH and inhibin B were inferior to the above measurements in terms of correlation with the ovarian response. In conclusion, dynamic measurements of inhibin B and oestradiol following single administration of buserelin acetate were highly correlated with the ovarian response to stimulation for IVF treatment.
Key words: GnRHa stimulation test/inhibin B/IVF/oestradiol/ovarian response
4 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Kaplan Medical Centre, POB 1, Rehovot 76100, Israel. E-mail: aravhon{at}bezeqint.net
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