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Human Reproduction, Vol. 15, No. 11, 2369-2370, November 2000
© 2000 European Society of Human Reproduction and Embryology

Offspring sex ratio of subfertile men and men with abnormal sperm characteristics

Rune Jacobsen1, Erik Bostofte, Niels E. Skakkebæk, Johnni Hansen and Henrik Møller

Department of Epidemiology, Institute of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

Previous work has suggested an association between male subfertility and a female-biased offspring sex ratio. This study of the reproduction of men who had a semen analysis at the Sperm Analysis Laboratory in Copenhagen in the period 1963–1993 showed that the subfertile men had an offspring sex ratio as expected (51.0% boys versus 51.3%, P = 0.56), and within the cohort, the offspring sex ratio had no material association with particular semen characteristics. Our results thus suggest that no important association exists between general male subfertility and a female-biased offspring sex ratio.

Key words: female-biased/male subfertility/offspring sex ratio

1 To whom correspondence should be addressed at: Department of Epidemiology, Institute of Public Health, Faculty of Health Sciences, University of Copenhagen, Panum Institute,Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.E-mail: R.jacobsen{at}pubhealth.ku.dk


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