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Human Reproduction, Vol. 15, No. 12, 2673-2683, December 2000
© 2000 European Society of Human Reproduction and Embryology

ESHRE Preimplantation Genetic Diagnosis (PGD) Consortium: data collection II (May 2000)

ESHRE PGD Consortium Steering Committee*

In 1997, the ESHRE PGD Consortium was formed as part of the ESHRE Special Interest Group on Reproductive Genetics, in order to undertake a long-term study of the efficacy and clinical outcome of preimplantation genetic diagnosis (PGD). In December 1999, the first PGD Consortium report was published discussing referrals of 323 couples, 392 PGD cycles and 82 pregnancies and 79 children born. In the second round of data collection, contributing centres were asked to send in data from their PGD activities before January 1997, as well as from 1st October 1998 until 1st May 2000, in order to have as complete as possible an overview of PGD practices in these centres. A further 563 referrals were sent in as well as 926 PGD cycles, and data on 89 pregnancies (including seven pregnancies ongoing from the previous group) and 83 children were collected. This has led to a considerable amount of cumulative data being acquired: over a period of 7 years (the oldest PGD cycle reported dates from 1994), referral data on 886 couples, cycle data on 1318 PGD cycles and data on 163 pregnancies and 162 babies were collected. In all, these data are encouraging: they show first, that the practice of PGD is becoming more and more established, and an increasing number of different applications is emerging; and second, that collecting these data is worthwhile, as they will be a valuable source of information for all those involved, e.g. in counselling patients and interacting with governmental bodies.

Key words: PGD cycle data/pregnancy and baby follow-up/preimplantation genetic diagnosis

1 To whom correspondence should be addressed.

* The ESHRE PGD Consortium Steering Committee: Joep Geraedts, Department of Molecular Cell Biology and Genetics, University of Maastricht, J. Bechlaan, 113, Maastricht, The Netherlands. E-mail joep.geraedts{at}gen.unimaas.nl

Alan Handyside (Chair, SIG in Reproductive Genetics), School of Biology, University of Leeds, Leeds, UK. E-mail A.H.Handyside{at}bmb.leeds.ac.uk

Joyce Harper, Department of Obstetrics and Gynaecology, University College London, 86–96 Chenies Mews, London WC1E 6HX, UK. E-mail joyce.harper{at}ucl.ac.uk

Inge Liebaers, Centre for Medical Genetics, Dutch-speaking Brussels Free University, Laarbeeklaan 101, 1090 Brussels, Belgium. E-mail lgenlsi{at}az.vub.ac.be

Karen Sermon1, Centre for Medical Genetics, Dutch-speaking Brussels Free University, Laarbeeklaan 101, 1090 Brussels, Belgium. E-mail lgensnk{at}az.vub.ac.be

Catherine Staessen, Centre for Reproductive Medicine, Dutch-speaking Brussels Free University, Laarbeeklaan 101, 1090 Brussels, Belgium. E-mail lriasnc{at}az.vub.ac.be

Alan Thornhill, Division of Reproductive Endocrinology and Infertility, Mayo Clinic, 200 First Street SW, Rochester MN 55905, USA. E-mail Thornhill.Alan{at}mayo.edu

Stéphane Viville, BP63, IGBMC, 1, Rue Laurent Fries, 67404 Illkirch-Strassbourg, France. E-mail viville{at}titus.u-strasbg.fr

Leeanda Wilton, Melbourne IVF, 320 Victoria Parade, 3002 East Melbourne VIC, Australia. E-mail Lwilton{at}mivf.com.au


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