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Human Reproduction, Vol. 15, No. 12, 2685, December 2000
© 2000 European Society of Human Reproduction and Embryology

Letters to the Editor

Chromosome analysis of spermatozoa extracted from testes of men with non-obstructive azoospermia

Leah Yogev1, Gedalia Paz and Haim Yavetz

Institute for the Study of Fertility, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Affiliated to the Tel-Aviv University, 6, Weizmann St., Tel Aviv, 64239, Israel

Dear Sir,

We read with great interest the recent article by Martin et al. (Martin et al. 2000Go). This first report on chromosomal aneuploidy in spermatozoa extracted from testes of patients with non-obstructive azoospermia suggested that certain azoospermic men are not at substantially increased risk for chromosomally abnormal spermatozoa. We would like to propose an explanation for the contradiction between this report and that of Huang et al. (Huang et al. 1999Go).

Using the fluorescence in-situ hybridization (FISH) technique, Huang et al. (1999) evaluated germ cells at different stages of spermatogenesis (except for spermatozoa) and found a high frequency of sex chromosome aneuploidy in haploid nuclei, ranging from 26.2 to 34.4% in men with impaired spermatogenesis, and 26% in the controls. This was . . . [Full Text of this Article]

Notes

References

Farideh Bischoff1 and Dolores J. Lamb

Department of Obstetrics and Gynecology, Baylor College of Medicine, Departments of Urology and Cell Biology, Baylor College of Medicine 6550 Fannin St, Suite 708, Houston, TX 77030, USA


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 J AndrolHome page
G. Paz, R. Gamzu, and H. Yavetz
Diagnosis of Nonobstructive Azoospermia: The Laboratory Perspective
J Androl, March 1, 2003; 24(2): 167 - 169.
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