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Human Reproduction, Vol. 15, No. 2, 314-318, February 2000
© 2000 European Society of Human Reproduction and Embryology

In-vitro fertilization in a spontaneous cycle: easy, cheap and realistic

R.M.J. Janssens1, C.B. Lambalk, J.P.W. Vermeiden, R. Schats and J. Schoemaker

Institute for Endocrinology, Reproduction and Metabolism, IVF Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands

The results of in-vitro fertilization in natural cycles (NIVF) in women with tubal infertility at our department are presented. The study had a prospective design. We needed 75 cycles in 50 patients to obtain one oocyte from each patient. Successful oocyte recovery rate was 67% per started cycle and 82% per oocyte retrieval. Thirty-five embryos were transferred and resulted in four ongoing pregnancies (5.3% per cycle, 6.5% per oocyte retrieval, 11.4% per embryo transfer and 11.4% per embryo). Six patients who participated in the study made a second attempt at NIVF. Five of them conceived of which four were ongoing. Cumulative ongoing pregnancy rates are 9.8% per cycle, 11.9% per oocyte retrieval, 19.5% per embryo transfer and 19.5% per embryo. We conclude that NIVF is an easy, cheap and realistic method to obtain a pregnancy for patients with tubal infertility.

Key words: HCG/IVF/natural cycle/pregnancy rates

1 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, IVF Center, PO Box 7057,1007 MB Amsterdam, The Netherlands

* *Long protocol including one strip of Microgynon 30, 3–4 weeks GnRH agonist Decapeptyl 100 µg/day (Ferring, Hoofddorp, The Netherlands), gonadotrophins Gonal F 150–450 IU/day for about 11 days (Serono), Profasi 10 000 IU (Serono, Den Haag, The Netherlands) and Progestan tablets 3x200 mg/day for 15 days (Organon, Oss, The Netherlands).


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