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Human Reproduction, Vol. 15, No. 2, 445-448, February 2000
© 2000 European Society of Human Reproduction and Embryology

Decreased sperm function of patients with myotonic muscular dystrophy

M.L. Hortas1,5, J.A. Castilla2, M.T. Gil3, J. Molina2, M.L. Garrido2, M. Morell4 and M. Redondo1

1 Unidad de Análisis Clínicos, Hospital Costa del Sol, 29600 Marbella, 2 Unidad de Reproducción, Hospital Virgen de las Nieves, 18014 Granada, 3 Servicio de Análisis Clínicos, Hospital Na Sra. del Prado, 45600 Talavera de la Reina and 4 Departmento de Bioquímica y Biología Molecular, Universidad de Málaga, 29080 Málaga, Spain

Myotonic muscular dystrophy (MMD) is a genetic disease caused by a defective enzyme, myotoninkinase. Male patients with MMD are reported to have reduced fertility. The purpose of this work was to study sperm capacitation and acrosome reaction in the ejaculates of sterile males with MMD and of healthy males (control group). The expression of the specific D-mannose receptors was explored by microscopic examination and by flow cytometry analysis. In addition, the binding patterns of Pisum sativum (PSA) lectin to acrosome content and outer acrosomal membrane in the spermatazoa of each group were analysed. Both the capacitation and the acrosome reaction in the spermatozoa of the MMD group were deficient and these findings strongly suggest that these anomalies may account for the sterility of these patients.

Key words: acrosome reaction/dystrophy/D-mannose/spermatozoa

5 To whom correspondence should be addressed


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