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Human Reproduction, Vol. 15, No. 4, 941-943, April 2000
© 2000 European Society of Human Reproduction and Embryology

Mannan-binding lectin concentration during normal human pregnancy

David C. Kilpatrick

Academic Unit, Department of Transfusion Medicine, 2 Forrest Road, Edinburgh EH1 2QN, UK

Relative deficiency of mannan-binding lectin (MBL) is associated with recurrent miscarriage. To investigate whether MBL concentration alters as a result of pregnancy, serial measurements were made in 14 patients before and during normal early pregnancy. Additionally, a longitudinal study was made of one individual over several years and including two normal pregnancies. Three (20%) subjects experienced a significant increase in MBL concentration during pregnancy. It was concluded that a modest but significant increase in MBL concentration can result from pregnancy, but it is a rare occurrence in the first trimester.

Key words: mannan-binding lectin/recurrent miscarriage/recurrent spontaneous abortion


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