Human Reproduction, Vol. 15, No. 4, 944-948,
April 2000
© 2000 European Society of Human Reproduction and Embryology
Incidence of congenital malformations in children born after ICSI
1 Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Göteborg, 2 Tornblad Institute, University of Lund and 3 Fertility Center Scandinavia, Carlanderska Hospital, Göteborg, Sweden
The aim of this study was to determine the incidence of congenital malformations in a complete cohort of children born after intracytoplasmic sperm injection (ICSI). The medical records were retrieved for 1139 infants, 736 singletons, 200 sets of twins and one set of triplets. The total number of infants with an identified anomaly was 87 (7.6%), 40 of which were minor. The incidence of malformations in children born after ICSI was also compared with all births in Sweden using data from the Swedish Medical Birth Registry and the Registry of Congenital Malformations. For ICSI children, the odds ratio (OR) for having any major or minor malformation was 1.75 [95% confidence interval (CI) 1.19–2.58] after stratification for delivery hospital, year of birth and maternal age. If stratification for singletons/twins was also done, the OR was reduced to 1.19 (95% CI 0.79–1.81). The increased rate of congenital malformations is thus mainly a result of a high rate of multiple births. The only specific malformation which was found to occur in excess in children born after ICSI was hypospadias (relative risk 3.0, exact 95% CI 1.09–6.50) which may be related to paternal subfertility.
Key words: intracytoplasmic sperm injection/malformations
4 To whom correspondence should be addressed at: Institute for Women's and Children's Health, Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Östra,416 85 Göteborg, Sweden
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