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Human Reproduction, Vol. 15, No. 4, 969-971, April 2000
© 2000 European Society of Human Reproduction and Embryology

Congenital malformations after intracytoplasmic injection of spermatids: Case report

H. Zech1,5, P. Vanderzwalmen2, Y. Prapas3, B. Lejeune2, E. Duba4 and R. Schoysman2

1 Institut für Reproduktionsmedizin und Endokrinologie, Bregenz, Austria, 2 Schoysman Infertility Management Foundation, Vilvoorde, Belgium, 3 4th University Clinic of Obstetrics and Gynecology, Hippocration General Hospital, Thessaloniki, Greece, and 4 Institut für Medizinische Biologie und Humangenetik der Universität Innsbruck, Innsbruck, Austria

Spermatid microinjection into oocytes was applied in cases of intracytoplasmic sperm injection (ICSI)/testicular sperm extraction (TESE) where no spermatozoa could be found in numerous testicular samples. Although several pregnancies were obtained with this procedure, serious concerns remain regarding its safety. Although the relevance of the injection of spermatids is by no means certain, we wish to report that from four pregnancies obtained after injection of elongated spermatids, two cases of major malformation resulted.

Key words: azoospermia/genetics/ICSI/malformation/spermatids

5 To whom correspondence should be addressed at: Römerstrasse 2, 6900 Bregenz, Austria


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