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Human Reproduction, Vol. 15, No. 5, 1061-1064, May 2000
© 2000 European Society of Human Reproduction and Embryology

Transfer of zona-free embryos improves outcome in poor prognosis patients: a prospective randomized controlled study

R.T. Mansour1, C.A. Rhodes, M.A. Aboulghar, G.I. Serour and A. Kamal

The Egyptian IVF-ET Centre, Cairo 11431, Egypt

Assisted zona hatching (AZH) has been used in IVF programmes for several years. Recently one group has reported successful pregnancies after transfer of zona-free blastocysts. The aim of our study was to evaluate outcomes after transfer of zona-free day 3 embryos. Two groups of women undergoing intracytoplasmic sperm injection (ICSI) were included in the study. Group A consisted of 52 women under the age of 40 years undergoing their first ICSI attempt. They were alternately randomized to receive zona-free embryos (27 women) and zona-intact embryos (25 women). The second group (group B) included 71 women with a poor prognosis, as defined by age 40 years or more, and/or at least two previous failed IVF/ICSI attempts. They were randomized in a 3:4 ratio (30 zona-free, 41 zona-intact). Acid Tyrode's solution was used to remove the zona pellucida before embryo transfer on day 3 after oocyte collection. The pregnancy rate in group A was not significantly improved when the zona pellucida was removed. However, in the poor prognosis group B, zona removal resulted in a significantly higher pregnancy rate when compared with controls (23 versus 7.3%). We conclude that complete removal of the zona pellucida can improve pregnancy rates in women with poor IVF/ICSI prognosis.

Key words: acid Tyrode's/hatching/ICSI/poor prognosis/zona-free embryo transfer

1 To whom correspondence should be addressed


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