Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Cohen, S. B.
Right arrow Articles by Schiff, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cohen, S. B.
Right arrow Articles by Schiff, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 15, No. 5, 1170-1172, May 2000
© 2000 European Society of Human Reproduction and Embryology

Anti-cardiolipin antibodies in fetal blood and amniotic fluid derived from patients with the anti-phospholipid syndrome

Shlomo B. Cohen1,3, Mordechai Goldenberg1, Jaron Rabinovici1, Arie L. Lidor1, Mordechai Dulitzky1, Boris Gilburd2, Yehuda Shoenfeld2 and Eyal Schiff1

1 Department of Obstetrics and Gynaecology and the Research Unit of Autoimmune Diseases and 2 Department of Medicine B Sheba Medical Centre, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Hashomer, Israel 52621

The aim of this study was to investigate whether, in patients with antiphospholipid syndrome, anticardiolipin antibodies pass from mother to offspring sera and amniotic fluid. Eleven patients with antiphospholipid syndrome (study group) and 11 healthy controls, matched by maternal and gestational age (control group) were prospectively examined for the presence of anticardiolipin antibodies in the cord blood during labour, and amniotic fluid during vaginal or Caesarean delivery. Three neonates (27.3%) in the study group had anticardiolipin antibodies in the cord blood, while none had them in the control group. Anticardiolipin antibodies were detected in the amniotic fluid in six (54.5%) of the study group pregnancies, compared with none in the control group. No adverse neonatal outcome was noted except for significantly lower (P < 0.0006) mean birth weight in the study group. Anticardiolipin antibodies can pass the placenta and be detected in fetal cord blood and amniotic fluid. This finding might be used in the future for the assessment of pregnancies with antiphospholipid syndrome.

Key words: amniotic fluid/anticardiolipin antibodies/antiphospholipid syndrome/fetal cord blood

3 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Sheba Medical Centre, Tel-Hashomer, Israel 52621


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 LupusHome page
M.-C. Boffa and E. Lachassinne
Review: Infant perinatal thrombosis and antiphospholipid antibodies: a review
Lupus, August 1, 2007; 16(8): 634 - 641.
[Abstract] [PDF]

Home page
 LupusHome page
M-C Boffa, M-H Aurousseau, E Lachassinne, H Dauphin, O Fain, P Le Toumelin, M Uzan, J-C Piette, S Derenne, C Boinot, et al.
European register of babies born to mothers with antiphospholipid syndrome
Lupus, September 1, 2004; 13(9): 713 - 717.
[Abstract] [PDF]

Home page
 Hum ReprodHome page
S. T. Matalon, M. Blank, Y. Levy, H. J.A. Carp, A. Arad, L. Burek, E. Grunebaum, Y. Sherer, A. Ornoy, S. Refetoff, et al.
The pathogenic role of anti-thyroglobulin antibody on pregnancy: evidence from an active immunization model in mice
Hum. Reprod., May 1, 2003; 18(5): 1094 - 1099.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
T Avcin, R Cimaz, and P L Meroni
Recent advances in antiphospholipid antibodies and antiphospholipid syndromes in pediatric populations
Lupus, January 1, 2002; 11(1): 4 - 10.
[Abstract] [PDF]

Home page
 LupusHome page
D Erkan, Y Yazici, and M D Lockshin
Lupus anticoagulant--hypoprothrombinemia syndrome and pregnancy
Lupus, April 1, 2001; 10(4): 311 - 312.
[PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.