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Human Reproduction, Vol. 15, No. 5, 1195-1197, May 2000
© 2000 European Society of Human Reproduction and Embryology

Pemphigus vulgaris in pregnancy: a case report and review of literature

Ofer Fainaru, Roy Mashiach, Michael Kupferminc, Michael Shenhav, David Pauzner and Joseph B. Lessing1

Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Israel

Pemphigus vulgaris (PV) is an uncommon, immune-mediated bullous dermatosis, which, during its active phase, has been associated with infertility. Pemphigus vulgaris during pregnancy is exceedingly rare—only 26 cases with immunopathological confirmation have been reported. The disease may be associated with adverse neonatal outcome, including prematurity and fetal death. Transient skin lesions may occasionally appear in the neonate. We report a patient who conceived during the active phase of PV, required high doses of corticosteroids to control the disease, and was delivered of a pre-term, appropriate-for-gestational age newborn.

Key words: pemphigus vulgaris/pregnancy

1 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, LisMaternity Hospital, Tel Aviv Sourasky Medical Center, 6 Weizman Street,Tel Aviv 64239, Israel


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